The role of anion channels in osmotically activated taurine release from embryonic skate (Raja eglanteria) heart

نویسندگان

  • Goldstein
  • Davis-Amaral
  • Blum
  • Luer
چکیده

Taurine, a major osmolyte of vertebrate hearts, is released from the skate heart at increased rates during hypotonic stress. We tested the hypothesis that this taurine release is mediated by chloride channels activated by swelling. Two inhibitors of the channels, NPPB and DIDS, inhibited the volume-activated release of taurine from embryonic skate hearts. These results support the hypothesis that swelling-activated chloride channels mediate the release of cardiac taurine.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Short Communication Taurine Transport Characteristics of the Embryonic Skate (raja Eglanteria) Heart

The hearts of elasmobranchs, like those of other vertebrates, accumulate high concentrations of the amino acid taurine (Boyd et al. 1977), which is used to maintain osmotic equilibrium with the extracellular fluid. We recently demonstrated that embryonic hearts of the clearnose skate (Raja eglanteria Bosc) were able to accumulate taurine equally as well as hearts of adult skates and, as in adul...

متن کامل

The absence of a photopic influence on the refractive development of the embryonic eye of the clearnose skate (Raja eglanteria)

The clearnose skate (Raja eglanteria) develops in an almost opaque eggcase and lays its eggs in pairs. One sibling from each of eight pairs of skates was removed from its eggcase during embryonic development, while the other sibling developed inside the eggcase. The refractive development of the eyes at hatching was examined to see if ambient light exposure during embryonic development could in...

متن کامل

Amino acids and cell regulation.

Free amino play an important role in regulating cell volume in fishes. Four tissues/cells (skeletal muscle, RBC, brain, and myocardium) of the little skate, Raja erinacea, were selected for detailed study because of their special importance or unique advantage as experimental models. Three particular amino acids, beta-alanine, taurine, and sarcosine play a predominant role in all four tissues. ...

متن کامل

Cell volume regulation: skating through the pathways.

BECAUSE EVERY CELLULAR FUNCTION is integrated directly or indirectly with every other, it is the webs of often highly evolutionarily conserved protein-protein interactions that define the cell (3). Maintenance of structure-function relationships is then prerequisite for cellular life, and these relationships dictate exquisite control of volume by most differentiated cells (7). It is the percept...

متن کامل

Metabolic Rate of Embryonic Little Skate, Raja erinacea (Chondrichthyes: Batoidea): The Cost of Active Pumping

Near-hatching embryonic little skates, Raja erinacea, are highly active within their egg capsules, displaying a characteristic tail beating, which pumps water through the capsule. We measured the metabolic rate of late-stage embryos to determine whether oxygen sufficient for the embryo’s needs will diffuse through the egg capsule, and to assess the energetic cost of tail beating. Metabolic rate...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of experimental biology

دوره 198 Pt 12  شماره 

صفحات  -

تاریخ انتشار 1995